This Week in PNAS

In PNAS this week, researchers in Pittsburgh report their findings that modification of ubiquitin carboxyl-terminal hydrolase L1 by cyclopentenone prostaglandins causes unfolding and aggregation of neurofribillary tangles. A single thiol group on Cys152 reacts with the α,β-unsaturated carbonyl center in the cyclopentenone ring of prostaglandins, resulting in a covalent adduct, the researchers write.

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The New York City medical examiner is overseeing an effort to identify missing persons using DNA, according to the Associated Press.

Nobel laureate Günter Blobel has died at 81, the New York Times reports.

In PNAS this week: mouse model of genetically induced emphysema, gene expression signatures of circulating melanoma cells, and more.

Technology Review reports that 2017 was the year of consumer genetic testing and that it could spur new analysis companies.