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In PNAS this week, researchers in Pittsburgh report their findings that modification of ubiquitin carboxyl-terminal hydrolase L1 by cyclopentenone prostaglandins causes unfolding and aggregation of neurofribillary tangles. A single thiol group on Cys152 reacts with the α,β-unsaturated carbonyl center in the cyclopentenone ring of prostaglandins, resulting in a covalent adduct, the researchers write.

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