This Week in PNAS

In PNAS this week, researchers in Pittsburgh report their findings that modification of ubiquitin carboxyl-terminal hydrolase L1 by cyclopentenone prostaglandins causes unfolding and aggregation of neurofribillary tangles. A single thiol group on Cys152 reacts with the α,β-unsaturated carbonyl center in the cyclopentenone ring of prostaglandins, resulting in a covalent adduct, the researchers write.

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Helix customers can purchase apps that interpret different aspects of their genome, Technology Review reports.

The New York Times reports that a number of companies and research institutes are pursuing gene therapies.

Salmon with shorter telomeres survive to make the trip back to their river homes, New Scientist reports.

In PLOS this week: vaginal microbiome composition, population patterns of Chagas-carrying Rhodnius ecuadoriensis, and more.