Researchers report their genome-wide association study for age-related macular degeneration in the PNAS Early Edition this week. By interrogating 2,157 cases and 1,150 controls, the team conferred AMD susceptibility loci and genotyped 30 "promising" markers in additional cohorts of up to 7,749 cases and 4,625 controls; here, they identified another susceptibility locus near TIMP3.