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In the Early Edition of PNAS this week, researchers identify 119 genes as potential drug targets — a finding they derived from a function-based gene identification using an shRNA library they constructed. The library contains about 150 shRNAs per gene investigated and was composed in an inducible lentiviral vector, enabling the propagation of growth-inhibiting shRNAS.

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Springer Nature announces €9,500 fee to make papers open-access in Nature and its family of journals.

Librarians have concluded that notebooks that belonged to Charles Darwin that were thought to have been lost were actually likely stolen, CNN reports.

An early SARS-CoV-2 alteration may have enabled it to spread more easily, according to the New York Times.

In PNAS this week: ultrarare variants contribute to aging-related hearing loss, telomeres of cells infected with herpesvirus, and more.