This Week in PNAS

This week in the PNAS Early Edition, researchers at the Washington University School of Medicine show that LRP6 silencing in breast cancer cells reduces Wnt signaling, cell proliferation, and tumor growth. Their results suggest that an LRP6 antagonist, Mesd, is a promising antitumor agent and potential therapeutic target for breast cancer subtypes with Wnt activation at the cell surface.

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Jay Shendure and his colleagues have developed a new method to more comprehensively identify human cell types, the NY Times reports.

Researchers in the UK and Japan have shown that infertility in mice with three sex chromosomes can be overcome, according to the Guardian.

China is embracing preimplantation genetic diagnosis, Nature News reports. 

In PLOS this week: host genetic factors associated with cervical neoplasia progression, population patterns for an ancient flowering rainforest plant, and more.