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Publishing in the online edition last week, research led by Vamsi Mootha and Sarah Calvo at the Broad Institute performed a genome-wide analysis of upstream ORFs and how they affect global protein expression. They looked at 11,649 matched mRNA and protein measurements from four published mammalian studies and selected 25 of them to perform reporter assays on. They estimated that uORFs typically reduce protein expression by 30 to 80 percent, with only a small impact on mRNA levels.

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