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Publishing in the online edition last week, research led by Vamsi Mootha and Sarah Calvo at the Broad Institute performed a genome-wide analysis of upstream ORFs and how they affect global protein expression. They looked at 11,649 matched mRNA and protein measurements from four published mammalian studies and selected 25 of them to perform reporter assays on. They estimated that uORFs typically reduce protein expression by 30 to 80 percent, with only a small impact on mRNA levels.

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The Wall Street Journal reports on gaps in COVID-19 testing affecting less affluent urban areas and rural locations.

According to NBC News, new SARS-CoV-2 variants are making it harder for researchers to model the course of the pandemic.

The New York Times reports that experts say President Joe Biden's goal of vaccinating 1 million people a day in the US in the next 100 days is too low a bar.

In Science this week: single-cell lineage tracing technique applied to study lung cancer metastasis, and more.