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In the PNAS Early Edition this week, an international research collaboration led by Chengjun Li at the University of Wisconsin-Madison describes their finding that genetic reassortment between the avian H5N1 and human H3N2 flu viruses causes hybrid strains with substantial virulence. To evaluate the pathogenic potential of these reassortant viruses, Li et al. created all 254 possible hybrids of H5N1 and H3N2 by using reverse genetics.

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The US Centers for Disease Control and Prevention has identified a small group of breakthrough COVID-19 cases, the Wall Street Journal reports.

The New York Times reports that the US Department of Defense is to use genetic genealogy approaches to identify the remains of unknown soldiers.

Vox and Nature discuss the importance of preparing for the next pandemic.

In Nature this week: comparison of five circulating tumor DNA assays, resequencing analysis of lettuce gives insight into its domestication, and more.