This Week in PNAS

In the PNAS Early Edition this week, an international research collaboration led by Chengjun Li at the University of Wisconsin-Madison describes their finding that genetic reassortment between the avian H5N1 and human H3N2 flu viruses causes hybrid strains with substantial virulence. To evaluate the pathogenic potential of these reassortant viruses, Li et al. created all 254 possible hybrids of H5N1 and H3N2 by using reverse genetics.

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While gene therapies may have high price tags, they could be cheaper than the cost of managing disease, according to MIT's Technology Review.

Researchers are looking for markers that indicate which cancer patients may respond to immunotherapies, the Associated Press writes.

In Nature this week: paternal age associated with de novo mutations in children, and more.

Nature News writes that researchers are still wrangling over the role of the p-value.