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In the PNAS Early Edition this week, researchers describe their discovery that amyloidogenic light chain (AL-LC) proteins induce oxidative stress, cellular dysfunction, and apoptosis in isolated adult cardiomyoctes through the activation of p38α mitogen-activated protein kinase. The team found the AL-LC-induced p38 activation to be independents of the upstream MAPK kinase, MKK3/6.

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Politico notes that the Biden Administration has not yet nominated a permanent Food and Drug Administration commissioner. 

Anthony Fauci also informed the World Health Organization executive board that the US would be joining the COVAX initiative, according to CNBC.

A new preprint suggests some SARS-CoV-2 variants could affect the effectiveness of current vaccines, the Associated Press reports.

In Nature this week: Australian lungfish provides details on the movement of vertebrate life from water to land, and more.