This Week in PNAS

In the PNAS Early Edition this week, researchers describe their discovery that amyloidogenic light chain (AL-LC) proteins induce oxidative stress, cellular dysfunction, and apoptosis in isolated adult cardiomyoctes through the activation of p38α mitogen-activated protein kinase. The team found the AL-LC-induced p38 activation to be independents of the upstream MAPK kinase, MKK3/6.

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An opinion piece in the Guardian argues that President Donald Trump is uninterested in science and that might not be a bad thing for the field.

The San Francisco Chronicle reports the Veterans Affairs Health System is studying whether genetic testing can help prescribe better depression therapies.

Stat News reports that Spark Therapeutics' Luxturna is now being used to treat a wider array of patients.

In Genome Biology this week: transcription factor among brittle stars, single-cell RNA sequencing strategy, and more.