This Week in PNAS: Feb 16, 2010

Feb 16, 2010

In the PNAS Early Edition this week, researchers describe their discovery that amyloidogenic light chain (AL-LC) proteins induce oxidative stress, cellular dysfunction, and apoptosis in isolated adult cardiomyoctes through the activation of p38α mitogen-activated protein kinase. The team found the AL-LC-induced p38 activation to be independents of the upstream MAPK kinase, MKK3/6.

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