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This week in the PNAS Early Edition, researchers show a relationship between RNA polymerases II and III by using ChIP-Seq studies to map their in vivo binding sites throughout the human genome. In the investigation of two cell lines, GM12878 and K562, Pol II was found to bind near many known Pol III genes, as well as a number of previously unidentified Pol III targets. The team also found that transcription factors normally associated with Pol II transcription were also closely connected with Pol-III-transcribed genes.

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