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In this week's PNAS, Wayne State University researchers report on a way to monitor DNA synthesis at the single base-pair level. By looking at single-molecule Förster resonance energy transfer, researchers led by David Rueda were able to see the incorporation of three nucleotides by the Escherichia coli DNA polymerase I. They then noted that the FRET efficiency drops off and then returns the expected level.

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Time magazine looks into how liquid biopsies are changing cancer care.

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In PNAS this week: similar muscle protein patterns across hypertrophic cardiomyopathy phenotypes, analysis of gene expression and brain anatomy in major depression, and more.