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In PNAS this week, Stanford University's Sebastian Maerkl and Stephen Quake study the evolution of transcription factors. In this work, they created all possible 95 single-point mutations of five DNA-contacting residues of Max, a human helix–loop–helix transcription factor, and then measured the DNA binding of each mutant.

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Librarians have concluded that notebooks that belonged to Charles Darwin that were thought to have been lost were actually likely stolen, CNN reports.

An early SARS-CoV-2 alteration may have enabled it to spread more easily, according to the New York Times.

In PNAS this week: ultrarare variants contribute to aging-related hearing loss, telomeres of cells infected with herpesvirus, and more.

NPR reports the US Food and Drug Administration has approved a treatment for a genetic disorder that causes rapid aging.