This Week in PNAS

In the current issue of PNAS, plant biologists show that SET7, a known histone methyltransferase, is involved in regulating the stability of DNA methyltransferase (DNMT1), which has a role in regulating cytosine DNA methylation in mammalian cells. SET7 interacts with DNMT1, they found, and overexpression of SET7 leads to decreased DNMT1 levels, while knockdown of SET7 stabilizes DNMT1.

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The UK's Nuffield Council on Bioethics says genetically modifying human embryos could be morally permissible, according to the Guardian.

A new Nature Biotechnology paper reports that CRISPR-Cas9 gene editing can lead to large deletions or complex rearrangements that could be pathogenic.

The Wall Street Journal likens a prototype developed by Synthetic Genomics to a "biological fax machine."

In PNAS this week: strategy for reactivating Rett syndrome-linked MECP2, small molecules able to suppress Staphylococcus aureus virulence, and more.