This Week in PNAS | GenomeWeb

This Week in PNAS

In the current issue of PNAS, plant biologists show that SET7, a known histone methyltransferase, is involved in regulating the stability of DNA methyltransferase (DNMT1), which has a role in regulating cytosine DNA methylation in mammalian cells. SET7 interacts with DNMT1, they found, and overexpression of SET7 leads to decreased DNMT1 levels, while knockdown of SET7 stabilizes DNMT1.

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Harold Varmus, a former NIH director, says that proposed reductions to the agency's budget are worrisome.

The Genome 10K project is to sequence about 10,000 vertebrate genomes, including ones of endangered species, Digital Trends reports.

The new Coalition to Save NIH Funding aims to educate lawmakers and the public on the significance of biomedical research.

In PLOS this week: analysis of viral sequences from human blood samples, gut microbiomes of heart failure patients, and more.