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In the Proceedings of the National Academy of Sciences this week, Graham Lord at King's College London has led a study that checked into the genetic factors behind the differentiation of CD4+ T helper cells. In searching for target genes of the transcription factors T-bet and GATA-3, which direct the differentiation of Th cells into Th1 and Th2 cells, they created a genomic map of T-bet and GATA-3 binding in primary human T cells.

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