This Week in PNAS

Characteristic mutations to the tumor suppressor gene TP53 do not seem to dial up copy-number changes in individuals with the cancer predisposition condition Li-Fraumeni syndrome, according to a study in the early, online edition of the Proceedings of the National Academies of Sciences. A team from the US, Malaysia, France, and Brazil did whole-genome sequencing on 13 individuals from two generations of a family affected by Li-Fraumeni syndrome.

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American scientists find themselves once again warning the Trump administration not to dismiss science, the New Yorker report.

A new study suggests CRISPR could be used to save coral reefs from dying off, Forbes reports.

Researchers have found that the i-motif shape of DNA previously observed in the lab also exists in human cells, and that it may serve a purpose.

In PNAS this week: a genomic, transcriptomic, and metabolomic analysis of the tea plant, Arabidopsis thaliana's adaptations to specific local environments, and more.