This Week in PNAS

Characteristic mutations to the tumor suppressor gene TP53 do not seem to dial up copy-number changes in individuals with the cancer predisposition condition Li-Fraumeni syndrome, according to a study in the early, online edition of the Proceedings of the National Academies of Sciences. A team from the US, Malaysia, France, and Brazil did whole-genome sequencing on 13 individuals from two generations of a family affected by Li-Fraumeni syndrome.

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Jay Shendure and his colleagues have developed a new method to more comprehensively identify human cell types, the NY Times reports.

Researchers in the UK and Japan have shown that infertility in mice with three sex chromosomes can be overcome, according to the Guardian.

China is embracing preimplantation genetic diagnosis, Nature News reports. 

In PLOS this week: host genetic factors associated with cervical neoplasia progression, population patterns for an ancient flowering rainforest plant, and more.