This Week in PNAS

In the early edition of the Proceedings of the National Academy of Sciences, researchers with Washington University's Center for Pharmacogenomics describe long non-coding RNAs that seem to appear to contribute to epigenetic regulation of transcripts in developing heart tissue. Through a combination of quantitative RNA sequencing and bioinformatics analyses on mouse embryonic heart tissue, the team tracked down more than 300 heart-expressed lncRNAs.

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Researchers hope to tease out the signature effects that different carcinogens leave on the genome to determine their contributions to disease, Mosaic reports.

An Imperial College London-led team reports that it was able to use a gene drive to control a population of lab mosquitos.

The Wall Street Journal looks into the cost of new gene therapies.

In PNAS this week: genomic effects of silver fox domestication, limited effect of mitochondrial mutations on aging in fruit flies, and more.