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In PNAS, there's no shortage of clinically oriented research. This paper from senior author Jeremy Nicholson and team use pharmacometabonomics to identify metabolic interactions in humans that depend on their microbiome; they urge an assessment of these microbial communities as "an integral part of pharmaceutical development and of personalized health care." Ian Wilson offers a commentary.

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In Science this week: gene expression signature linked to nonalcoholic fatty liver disease progression, and more.