This Week in PNAS

In a study slated to appear in the early, online edition of the Proceedings of the National Academy of Sciences this week, an Ohio State University-led team assessed the expression of hundreds of microRNAs in ovarian cancer tumors, looking for those with expression profiles that coincided with chemotherapy resistance. Through an array-based analysis of almost 700 microRNAs in tumor samples from 86 women with ovarian cancer, researchers tracked down a 23-miRNA signature for chemoresistance.

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The US Food and Drug Administration has new guidelines that enable some gene and cell therapies to undergo expedited review, according to the New York Times.

Using gene drives to control invasive species might be too risky, an initial advocate of the approach says.

In Science this week: intellectual property experts argue patent battles such as the one over CRISPR are wasteful, and more.

Researchers have grown tumors in 3D cell cultures to better understand cancer, the Economist reports.