This Week in PNAS

In the early online edition of PNAS, scientists from Imperial College London and Pfizer report a successful application of metabolic profiling. Using NMR to profile the urine of 99 men who were given acetaminophen, they found that those with higher initial levels of p-cresol sulfate metabolized the drug less effectively than those with lower levels.

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Rare gene mutations are guiding the search for drugs to manage chronic pain without opioids, according to CNBC.

The new Francis Crick Institute building can get too noisy for some researchers to concentrate, according to the Guardian.

CBS News reports that there are still many vacancies at the White House Office of Science and Technology Policy, but that it's uncertain whether they will be filled.

In Nucleic Acids Research this week: pipeline to analyze and visualize bacterial genomes, database of global set of human genomes, and more.