This Week in PNAS

A Memorial Sloan-Kettering Cancer Center-led team presents a model for doing integrated analyses of cancer genomes in a study slated to appear online this week in the Proceedings of the National Academy of Sciences. Using data from the Cancer Cell Line Encyclopedia and The Cancer Genome Atlas, the researchers demonstrated that their statistical framework — called iCluster+ — accurately classified hundreds of cancer cell lines by sites of origin, subgroup, and so on.

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Microsoft co-founder Paul Allen also contributed to brain research, NPR reports.

The New York Times reports on the shifting interpretations of what some genetic variants mean over time.

In Cell this week: investigation of metastatic tumor evolution, more than 16,000 genetic variants introduced into the budding yeast model organism, and more.

MIT's Technology Review reports on Genentech's pursuit of personalized cancer vaccines.