This Week in PNAS

In a study set to appear online this week in the Proceedings of the National Academy of Sciences, Rockefeller University researchers Fang-Yuan Chang and Sean Brady describe a homology-guided approach for finding new natural products using metagenomic sequence data. The pair demonstrated the feasibility of this method using bulk bacterial DNA from a desert soil sample collected in California, looking in particular for sequences encoding indolotryptoline-based compounds with anti-proliferative activity.

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Two researchers have found that behavioral genetic defenses in criminal cases don't tend to affect outcomes, according to Popular Science.

Researchers report that while host genetics influence the oral microbiome, they don't appear to affect cavity-causing microbes, the Economist says.

Pandas' gut microbiomes change as what they eat changes with the seasons, writes Discover's Inkfish blog.

In PLOS this week: comparative genomic study of malaria-linked macaque parasite, search for apple root reference genes, and more.