This Week in PNAS | GenomeWeb

This Week in PNAS

In a study set to appear online this week in the Proceedings of the National Academy of Sciences, Rockefeller University researchers Fang-Yuan Chang and Sean Brady describe a homology-guided approach for finding new natural products using metagenomic sequence data. The pair demonstrated the feasibility of this method using bulk bacterial DNA from a desert soil sample collected in California, looking in particular for sequences encoding indolotryptoline-based compounds with anti-proliferative activity.

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In PLOS this week: genetic study of breast cancer in Egyptian families, mutations linked to cleft lip and palate, and more.

Council Bluffs, Iowa, schools are encouraging more girls to pursue STEM courses, according to the Associated Press.

Because of new open-access requirements, Gates Foundation-funded researchers can't publish in some top journals, Nature News reports.

In Science this week: deletion of one microRNA allows pluripotent stem cells to form embryonic and non-embryonic lineages, and more.