This Week in PNAS

In a study set to appear online this week in the Proceedings of the National Academy of Sciences, Rockefeller University researchers Fang-Yuan Chang and Sean Brady describe a homology-guided approach for finding new natural products using metagenomic sequence data. The pair demonstrated the feasibility of this method using bulk bacterial DNA from a desert soil sample collected in California, looking in particular for sequences encoding indolotryptoline-based compounds with anti-proliferative activity.

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The London School of Economics' Daniele Fanelli argues at the Proceedings of the National Academy of Sciences that the reproducibility crisis in science isn't as dire as some say.

A team of researchers in Portugal has examined the genomic basis for racing pigeons' athleticism and navigational skills, finding it's likely polygenic.

Wired reports that diagnostic firms continue to seek, post-Theranos, the ability to diagnose diseases from small amounts of blood.

In Science this week: analysis of DNA from ancient North Africans, and more.