This Week in PNAS

Unintentional physical interactions between proteins crowded together in the same cell can influence proteome evolution and function, according to a study in the early, online edition of the Proceedings of the National Academy of Sciences. An international team led by investigators in the UK looked at relationships between the three-dimensional structure of proteins and their abundance.

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Rob Knight writes at Scientific American that microbiome studies are about to break out of the laboratory.

Harold Varmus, the director of the National Cancer Institute, has announced that he is stepping down after nearly five years.