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This Week in PNAS: Jun 12, 2012

In a paper published online in advance in PNAS this week, an international team led by investigators at the Centro Nacional de Biotecnología in Madrid presents a single-nucleotide resolution level DNA methylation analysis of newborn and centenarian genomes using whole-genome bisulfite sequencing. Overall, the team reports having found that "the centenarian DNA had a lower DNA methylation content and a reduced correlation in the methylation status of neighboring cytosine-phosphate-guanine throughout the genome in comparison with the more homogeneously methylated newborn DNA."

Elsewhere, Northwestern University's Christopher Kuzawa and his colleagues show that the association of paternal age with offspring telomere length "is cumulative across multiple generations." In the sample they studied, Kuzawa et al., found that "grandchildren of older paternal grandfathers at the birth of fathers have longer telomeres, independent of, and additive to, the association of their father's age at birth with TL [telomere length]," they report.

And researchers at Japan's University of Tsukuba show in PNAS this week that G13997A mtDNA regulates diabetes development, lymphoma formation, and metastasis in a transmitochondrial mouse model.

The Scan

Billions for Antivirals

The US is putting $3.2 billion toward a program to develop antivirals to treat COVID-19 in its early stages, the Wall Street Journal reports.

NFT of the Web

Tim Berners-Lee, who developed the World Wide Web, is auctioning its original source code as a non-fungible token, Reuters reports.

23andMe on the Nasdaq

23andMe's shares rose more than 20 percent following its merger with a special purpose acquisition company, as GenomeWeb has reported.

Science Papers Present GWAS of Brain Structure, System for Controlled Gene Transfer

In Science this week: genome-wide association study ties variants to white matter stricture in the brain, and more.