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In this week's PNAS Early Edition, researchers at the Cold Spring Harbor Laboratory in New York and their collaborators present evidence to suggest that "large cancer-associated deletions can produce phenotypes distinct from those arising through loss of a single TSG [tumor-suppressor gene], and as such should be considered and studied as distinct mutational events." The team tested its hypothesis — that large chromosomal deletions "can arise from selective pressure to attenuate the activity of multiple genes" — in a murine model of hepatocellular carcinoma using in vivo R

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Moderna reports its vaccine is effective against new SARS-CoV-2 strains, though it is also developing a booster, according to the New York Times.

A new analysis suggests the B.1.1.7 strain of SARS-CoV-2 could be deadlier than previous ones, according to the Guardian.

NPR reports Merck is halting the development of its two candidate SARS-CoV-2 vaccines following disappointing Phase 1 results.

In PLOS this week: gene mutation linked to inherited venous thrombosis, lncRNA patterns in the Asian tiger mosquito, and more.