This Week in PNAS | GenomeWeb

This Week in PNAS

In this week's PNAS Early Edition, researchers at the Cold Spring Harbor Laboratory in New York and their collaborators present evidence to suggest that "large cancer-associated deletions can produce phenotypes distinct from those arising through loss of a single TSG [tumor-suppressor gene], and as such should be considered and studied as distinct mutational events." The team tested its hypothesis — that large chromosomal deletions "can arise from selective pressure to attenuate the activity of multiple genes" — in a murine model of hepatocellular carcinoma using in vivo R

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Harold Varmus, a former NIH director, says that proposed reductions to the agency's budget are worrisome.

The Genome 10K project is to sequence about 10,000 vertebrate genomes, including ones of endangered species, Digital Trends reports.

The new Coalition to Save NIH Funding aims to educate lawmakers and the public on the significance of biomedical research.

In PLOS this week: analysis of viral sequences from human blood samples, gut microbiomes of heart failure patients, and more.