Using ChIP-seq to define TEAD4 target genes genome-wide to decipher how their transcription is maintained in the trophectoderm in a preimplantation mouse embryo model, a team led by researchers at the University of Kansas Medical Center found that a "lack of nuclear localization of TEAD4 impairs the TE [trophectoderm]-specific transcriptional program in inner blastomeres, thereby allowing their maturation toward the ICM [inner cell mass] lineage." In a paper published online in advance in