In this week's PNAS Early Edition, investigators at the University of California, Irvine, and at Metabolon discuss their analysis of "a comprehensive dataset of over 500 metabolites identified by mass spectrometry," which, through computational modeling, helped them to uncover "evidence of synergistic nodes between the circadian transcriptome and specific metabolic pathways." The public-private team presents an integrated map that it says "illustrates the coherence within the circadian