This Week in PNAS

In this week's PNAS Early Edition, investigators at the University of California, Irvine, and at Metabolon discuss their analysis of "a comprehensive dataset of over 500 metabolites identified by mass spectrometry," which, through computational modeling, helped them to uncover "evidence of synergistic nodes between the circadian transcriptome and specific metabolic pathways." The public-private team presents an integrated map that it says "illustrates the coherence within the circadian

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Researchers hope to tease out the signature effects that different carcinogens leave on the genome to determine their contributions to disease, Mosaic reports.

The Wall Street Journal looks into the cost of new gene therapies.

An Imperial College London-led team reports that it was able to use a gene drive to control a population of lab mosquitos.

In PNAS this week: genomic effects of silver fox domestication, limited effect of mitochondrial mutations on aging in fruit flies, and more.