This Week in PNAS | GenomeWeb

This Week in PNAS

In a paper appearing in this week's Early Edition, researchers at Johns Hopkins University School of Medicine and at the University of California, Irvine, show that deletion of Lhx2 in aging mice induces constitutive reactive gliosis, which then reduces "rates of ongoing apoptosis and compromised both rod and cone photoreceptor function." The Hopkins-Irvine team adds that these animals also "showed a dramatically reduced ability to induce expression of secreted neuroprotective factors and displayed enhanced rates of apoptosis in light-damage assays." Overall, the researchers say their study

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The White House has created a list of cuts, including to the NIH, that could be in a budget bill for this year.

The US National Institutes of Health is to allow applicants to cite preprints just as they would any other research paper, ScienceInsider reports.

Two manuscript pages handwritten by Charles Darwin are going on the auction block, according to the Los Angeles Times.

In PNAS this week: tool to track transcriptome-wide binding, evidence of balancing selection on behavior-linked genes, and more.