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This Week in PNAS : Jan 17, 2012

In an article appearing in this week's PNAS Early Edition, an international team led by investigators at the University of British Columbia reports using mutagenesis and mass spectrometry techniques to find that, "besides directing ORF2 translation, the Israeli acute paralysis dicistrovirus IRES also directs ORFx translation." The team shows that the latter form "is mediated by a U-G base pair adjacent to the P-site tRNA-mimicking domain." The team also detected an ORFx peptide in virus-infected honey bees.

Elsewhere, using yeast complementation assays and an in planta application of lovastatin, researchers in France and Switzerland show that "defects in HMG1 catalytic activity are sufficient to inhibit miRNA activity." Moreover, the team says its results "suggest a possible basis for the requirement of isoprenoid biosynthesis for the activity of plant miRNAs, and unravel mechanistic features shared with their metazoan counterparts."

The Scan

Boosters Chasing Variants

The New York Times reports that an FDA advisory panel is to weigh updated booster vaccines for COVID-19.

Not Yet

The World Health Organization says monkeypox is not yet a global emergency, the Washington Post reports.

More Proposed for Federal Research

Science reports that US House of Representatives panels are seeking to increase federal research funding.

PLOS Papers on Breast Cancer Metastasis, Left-Sided Cardiac Defects, SARS-CoV-2 Monitoring

In PLOS this week: link between breast cancer metastasis and CLIC4, sequencing analysis of left-sided cardiac defects, and more.