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This Week in PNAS : Jan 17, 2012

In an article appearing in this week's PNAS Early Edition, an international team led by investigators at the University of British Columbia reports using mutagenesis and mass spectrometry techniques to find that, "besides directing ORF2 translation, the Israeli acute paralysis dicistrovirus IRES also directs ORFx translation." The team shows that the latter form "is mediated by a U-G base pair adjacent to the P-site tRNA-mimicking domain." The team also detected an ORFx peptide in virus-infected honey bees.

Elsewhere, using yeast complementation assays and an in planta application of lovastatin, researchers in France and Switzerland show that "defects in HMG1 catalytic activity are sufficient to inhibit miRNA activity." Moreover, the team says its results "suggest a possible basis for the requirement of isoprenoid biosynthesis for the activity of plant miRNAs, and unravel mechanistic features shared with their metazoan counterparts."

The Scan

Another Resignation

According to the Wall Street Journal, a third advisory panel member has resigned following the US Food and Drug Administration's approval of an Alzheimer's disease drug.

Novavax Finds Its Vaccine Effective

Reuters reports Novavax's SARS-CoV-2 vaccine is more than 90 percent effective in preventing COVID-19.

Can't Be Used

The US Food and Drug Administration says millions of vaccine doses made at an embattled manufacturing facility cannot be used, the New York Times reports.

PLOS Papers on Frozen Shoulder GWAS, Epstein-Barr Effects on Immune Cell Epigenetics, More

In PLOS this week: genome-wide association study of frozen shoulder, epigenetic patterns of Epstein-Barr-infected B lymphocyte cells, and more.