This Week in PNAS

Researchers at the University of California, Berkeley, identify two regions of the double-pleckstrin homology domain architecture of Rtt106 that mediate histone binding, as they report in the PNAS Early Edition this week. "When histone binding was compromised, Rtt106 localized properly to chromatin but failed to deliver H3K56ac, leading to replication and silencing defects," the Berkeley team found.

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Researchers find that a personalized medicine approach could help people who experience pain while taking statins, New Scientist reports.

US National Science Foundation is continuing its responsible research conduct training policy despite its flaws, ScienceInsider reports.

A CRISPR-themed meeting explored how the tool could and should be used, Wired reports.

In Science this week: database of proteins' effects on cancer, targeted error correction sequencing, and more.