This Week in PNAS

In this week's PNAS Early Edition, the University of Alberta's Ling-ju Lin and Michael Schultz discuss promoter-targeted Rtt109 repression of ARG1 via "silencing a pathway of transcriptional activation that depends on ASF1." Lin and Schultz show that the intensity of ARG1 transcription "at its induced and repressed set points is controlled by different mechanisms of functional interplay between Rtt109 and Asf1."

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A fire at a Manchester hospital may have destroyed lab equipment and data, the Guardian reports.

Researchers generate a genetic database from skeletal remains from the 1845 Franklin Expedition to the Arctic, Live Science reports.

Researchers in China have begun another trial using CRISPR/Cas9 approaches in cancer patients, according to the Wall Street Journal.

In Science this week: human DNA found in sediments from archeological sites lacking bones, and more.