In PNAS this week, scientists at UNC Chapel Hill have used computational prediction to identify a unique motif that is recognized and bound only by the yeast Type I Hsp40s Ydj1. Heat shock proteins such as Ydj1 play a role in refolding damaged proteins. A yeast proteome screen revealed that many proteins contain more than one stretch of residues that contain the motif and are separated by varying numbers of amino acids, they say.