This Week in PNAS

In PNAS this week, a team of US researchers present a study on the conformational trapping of mismatch recognition complex MSH2/MSH3 on repair-resistant DNA loops. MSH2/MSH3 discriminates between repair-competent and repair-resistant loops by "sensing the conformational dynamics of their junctions," the authors write. MSH2/MSH3 dissociates from repair-competent loops, but repair-resistant CAG loops trap nucleotide-bound MSH2/MSH3 and don't allow it to dissociate from DNA.

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Gene drives might run into biological resistance, the Economist reports.

Forensic experts exhumed painter Salvador Dalí's body to collect DNA for a paternity test, CBS News reports.

Yale Environment 360 writes that synthetic and conservation biologists aren't always on the same wavelength, but they are trying to reach an understanding.

In Science this week: full CRISPR locus integration complex structure, and more.