This Week in PNAS

In this week's PNAS Early Edition, the University of Washington's Jay Shendure and his colleagues report on their exome sequencing study of 23 prostate cancers derived from 16 different lethal metastatic tumors and three high-grade primary carcinomas, through which they uncovered a "spectrum of mutation frequencies in advanced and lethal prostate cancers." The team shows that "point mutations arising in coding regions of advanced prostate cancers are common but, with notable excepti

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American scientists find themselves once again warning the Trump administration not to dismiss science, the New Yorker report.

A new study suggests CRISPR could be used to save coral reefs from dying off, Forbes reports.

Researchers have found that the i-motif shape of DNA previously observed in the lab also exists in human cells, and that it may serve a purpose.

In PNAS this week: a genomic, transcriptomic, and metabolomic analysis of the tea plant, Arabidopsis thaliana's adaptations to specific local environments, and more.