This Week in PNAS

Researchers at the Harvard School of Public Health and their collaborators show in this week's PNAS Early Edition that "cigarette smoking increases copy number alterations in non-small cell lung cancer." The team reports results of a genome-wide study of DNA copy number and smoking pack-years on 264 NSCLC tumors, divided into discovery and validation sets. "We found that heavy cigarette smokers ([fewer than] 60 pack-years) have significantly more copy number gains than non- or light smokers ([more than or equal to] 60 pack-years) ...

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