This Week in PNAS

In this week's PNAS Early Edition, investigators at the University of Iowa Carver College of Medicine report their use of exome sequencing "to identify a homozygous Alu insertion in exon 9 of male germ cell-associated kinase as the cause of disease in an isolated individual with RP," or retinitis pigmentosa. The Iowa team screened 1,798 additional, unrelated RP patients and found 20 others who, like the proband, were homozygous for this insertion.

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23andMe's Anne Wojcicki ponders DNA and what it means to be human in a New York Times essay.

A new estimate places the last universal common ancestor to life on Earth as living 3.9 billion years ago, Inverse reports.

In PNAS this week: retinitis pigmentosa gene therapy, role of microbiome in growth stunting, and more.

Bloomberg reports that researchers and drug companies are modeling anti-obesity treatments after the rare genetic condition essential fructosuria.