This Week in PNAS

In a paper published online in advance in the PNAS Early Edition this week, a team led by investigators at Harvard Medical School shows that, in a mouse model of pancreatic neuorendocrine cancer, administration of the endogenous angiogenesis inhibitors endostatin, thrombospondin-1, and tumstatin peptides, "as well as deletion of their genes, reveal neoplastic stage-specific effects on angiogenesis, tumor progression, and survival, correlating with endothelial expression of their receptors." Further, the team reports its finding that the deletion of tumstatin and thrombospondin-1 in

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23andMe's Anne Wojcicki ponders DNA and what it means to be human in a New York Times essay.

A new estimate places the last universal common ancestor to life on Earth as living 3.9 billion years ago, Inverse reports.

In PNAS this week: retinitis pigmentosa gene therapy, role of microbiome in growth stunting, and more.

Bloomberg reports that researchers and drug companies are modeling anti-obesity treatments after the rare genetic condition essential fructosuria.