This Week in PNAS

In the PNAS Early Edition this week, Cold Spring Harbor Laboratory's Scott Lowe and his colleagues "demonstrate the feasibility of transgenic inducible RNAi for suppression of essential genes." In an adult mouse model, Lowe's team targeted cell proliferation by screening an RNAi library against DNA replication factors; the group identified multiple short hairpin RNAs against Replication Protein A, subunit 3 — RPA3 — and, subsequently, "generated transgenic mice with TRE-driven Rpa3 shRNAs whose expression enforced a reversible cell cycle arrest," it writes.

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Researchers have treated an X-linked genetic disease affecting three babies in utero, Stat News reports.

The Associated Press reports that the US Centers for Disease Control and Prevention is beefing up sequencing as a tool to investigate foodborne illnesses.

Researchers have sequenced samples from ancient toilets to study past eating habits and health, NPR reports.

In Nature this week: ash dieback disease fungal genome, and more.