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This Week in PNAS

In the PNAS Early Edition this week, Cold Spring Harbor Laboratory's Scott Lowe and his colleagues "demonstrate the feasibility of transgenic inducible RNAi for suppression of essential genes." In an adult mouse model, Lowe's team targeted cell proliferation by screening an RNAi library against DNA replication factors; the group identified multiple short hairpin RNAs against Replication Protein A, subunit 3 — RPA3 — and, subsequently, "generated transgenic mice with TRE-driven Rpa3 shRNAs whose expression enforced a reversible cell cycle arrest," it writes.

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Bloomberg reports that the DNA-for-cash deal reported in Kentucky might be a more widespread scam.

St. Jude Children's Research Hospital scientists have treated infants with X-linked severe combined immunodeficiency using gene therapy in an early phase study.

St. Louis Public Radio reports that some African Americans are turning to DNA ancestry testing to help guide genealogical searches.

In Nature this week: a genomic analysis of the snailfish Pseudoliparis swirei, ancient DNA analysis gives insight into the introduction of farming to England, and more.