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In the PNAS Early Edition this week, Cold Spring Harbor Laboratory's Scott Lowe and his colleagues "demonstrate the feasibility of transgenic inducible RNAi for suppression of essential genes." In an adult mouse model, Lowe's team targeted cell proliferation by screening an RNAi library against DNA replication factors; the group identified multiple short hairpin RNAs against Replication Protein A, subunit 3 — RPA3 — and, subsequently, "generated transgenic mice with TRE-driven Rpa3 shRNAs whose expression enforced a reversible cell cycle arrest," it writes.

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SARS-CoV-2 vaccine developers are evaluating further vaccine doses as well as modified doses to keep up with new viral variants, according to CNN.

The New York Times reports that a new viral variant of concern has been identified in New York City.

In Nature this week: spatiotemporally resolved map of the human cell cycle, folding single-cell RNA sequencing into cancer drug studies, and more.

According to BBC News, the global vaccine-sharing initiative has sent its first shipment, which arrived in Ghana this week.