This Week in PNAS

In this week's PNAS Early Edition, investigators at the University of Edinburgh in the UK show that "transcriptionally repressed genes become aberrantly methylated and distinguish tumors of different lineages in breast cancer." More specifically, in its investigation of promoter methylation in 19 breast cancer cell lines and 47 primary breast tumors, the team found "120 genes that were significantly repressed in association with methylation," which "allowed the unsupervised segregation of cell lines into epithelial and mesenchymal lineages." The Edinburgh team says that aberrant

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Gene drives might run into biological resistance, the Economist reports.

Forensic experts exhumed painter Salvador Dalí's body to collect DNA for a paternity test, CBS News reports.

Yale Environment 360 writes that synthetic and conservation biologists aren't always on the same wavelength, but they are trying to reach an understanding.

In Science this week: full CRISPR locus integration complex structure, and more.