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This Week in PNAS

In this week's PNAS Early Edition, investigators at the University of Edinburgh in the UK show that "transcriptionally repressed genes become aberrantly methylated and distinguish tumors of different lineages in breast cancer." More specifically, in its investigation of promoter methylation in 19 breast cancer cell lines and 47 primary breast tumors, the team found "120 genes that were significantly repressed in association with methylation," which "allowed the unsupervised segregation of cell lines into epithelial and mesenchymal lineages." The Edinburgh team says that aberrant

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As we enter conference season, Nature News asks why graduate students and postdocs are sometimes forced to choose between paying the rent and paying to attend important meetings.

A new analysis says that a 2018 study claiming to show biparental mtDNA inheritance has several flaws.

In PNAS this week: a genome sequence analysis of Crucihimalaya himalaica, multicellularity and fruiting body development in mushroom-forming fungi, and more.

Two researchers are calling for education for scientists on defending facts.