This Week in PLoS | GenomeWeb

This Week in PLoS

In PLoS Biology this week, investigators at the University of Toronto report that most "dark matter" transcripts are associated with known genes in the mouse and human genomes. Using a combination of RNA-seq information and data obtained from tiling arrays experiments, the team shows that most of the seqfrags — or transcribed regions outside known exons and non-coding RNAs — are within introns, "raising the possibility that they are fragments of pre-mRNAs," they write.

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The Wall Street Journal reports that National Institutes of Health Director Francis Collins' response to contamination concerns at the agency might have delayed care.

The final revision of the Common Rule doesn't include the proposed change requiring consent for leftover biospecimens.

The first Reproducibility Project: Cancer Biology papers show mixed results.

In Nature this week: mobile phone-based targeted DNA sequencing, and more.