This Week in PLoS

In PLoS One this week, researchers suggest that "re-annotation should be considered to be an essential first step for deriving value from functional genomics data" because it can produce unique knowledge derived from previous research findings. In any systems biology modeling of functional genomics data, the authors say, structural and functional re-annotation is critical — particularly for species with recently sequenced genomes.

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Microsoft co-founder Paul Allen also contributed to brain research, NPR reports.

The New York Times reports on the shifting interpretations of what some genetic variants mean over time.

In Cell this week: investigation of metastatic tumor evolution, more than 16,000 genetic variants introduced into the budding yeast model organism, and more.

MIT's Technology Review reports on Genentech's pursuit of personalized cancer vaccines.