This Week in PLoS

In PLoS Biology this week, Duke University researcher David Goldstein and his co-workers report that "synthetic associations" between rare and common variants may be behind the results of some genome-wide association studies. The conclusion is based on the team's simulation experiments as well as GWAS of sickle cell anemia and hearing loss. "[E]ven those signals that have been detected for common variants could, in principle, come from the effect of rare ones," they write.

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Rare gene mutations are guiding the search for drugs to manage chronic pain without opioids, according to CNBC.

The new Francis Crick Institute building can get too noisy for some researchers to concentrate, according to the Guardian.

CBS News reports that there are still many vacancies at the White House Office of Science and Technology Policy, but that it's uncertain whether they will be filled.

In Nucleic Acids Research this week: pipeline to analyze and visualize bacterial genomes, database of global set of human genomes, and more.