In work published in PLoS One this week, scientists at Baylor College of Medicine have used high-throughput, single-cell analysis to study the androgen receptor -- specifically, its ligand binding activity, cell cycle progression, and mutation-specific effects.
NYU scientists in PLoS Biology explored how phenotypic capacitors like Hsp90 can regulate phenotypic robustness. In the study, they used high-throughput morphological phenotyping of individual yeast cells from single-gene deletion strains to identify gene products that protect against environmental variation in S. cerevisiae. Among the more than 300 gene products were those that control chromosome organization and DNA integrity, RNA elongation, protein modification, cell cycle, and response to stimuli like stress.
In PLoS Computational Biology, there’s a review about the "current chilly state of digital libraries for the computational biology." The British authors discuss current databases like PubMed and IEEE Xplore; and then talk about how new Web 2.0 apps such as Zotero, Mendeley, MyNCBI, and CiteULike can make bibliographic data more accessible.
Research out of Brad Bernstein's lab used ultra-high-throughput sequencing to map polycomb-group complexes across the genomes of human and mouse ES cells. The scientists found two classes of bivalent domains with distinct regulatory properties and were able to predict that the locations of PRC2 and PRC1 are associated with CpG islands. Their work was published in PLoS Genetics last week.