Skip to main content
Premium Trial:

Request an Annual Quote

This Week in PLoS: Jan 26, 2010

In PLoS ONE this week, Danish researchers report on their analysis of insertions and deletions in the human genome. The team sifted through published re-sequencing data in the Seattle SNPs and National Institute of Environmental Health Sciences databases to find polymorphism patterns in the human genome, comparing these with chimpanzee indels. "Our data strongly suggest that deletions are more deleterious than insertions," they write, "but that insertions and deletions are otherwise generally governed by the same genomic factors."

J. Craig Venter Institute and Macquarie University researcher Ian Paulsen and his team describe their sequencing and analysis of the genome of an antibiotic resistant Pseudomonas aeruginosa strain called PA7 from Argentina. After using a whole-genome shotgun approach to sequence the 6.6 million base genome, the researchers compared the sequence to that of other strains, identifying virulence factors, genes involved in antibiotic resistance, and more.

As part of the Trial of Infant Probiotic Supplementation or TIPs study, University of California of San Francisco gastroenterologist Susan Lynch and her co-workers investigate how the infant gut microbiome changes in babies given Lactobacillus casei subspecies rhamnosus supplements. As part of the double blind, randomized trial, the team used 16S rRNA PhyloChip to compare the gut microbial community in infants receiving the supplements for their first six months with infants receiving a placebo. Their results suggest the L. casei supplements are linked to gut microbial communities containing other known probiotics, including Lactobacillaceae and Bifidobacteriaceae species.

A team of researchers from the UK and US report that they have sequenced the genome of an Escherichia coli strain called E. coli 042. First isolated from a child with diarrhea in Peru in the early 1980s, the strain belongs to a group of intestinal infection-causing bacteria called enteroaggregative E. coli. The researchers sequenced the genome to about eight times coverage and used microarrays to profile the bug's metabolism, turning up differences between E. coli 042 and other E. coli strains. "This study provides a genetic context for the vast amount of experimental and epidemiological data published thus far and provides a template for future diagnostic and intervention strategies," they write.

The Scan

Long COVID-19 Susceptibility Clues Contained in Blood Plasma Proteome

A longitudinal study in eBioMedicine found weeks-long blood plasma proteome shifts after SARS-CoV-2 infection, along with proteomic signatures that appeared to coincide with long Covid risk.

Tibetan Study Finds Adaptive Variant Influencing Skin Pigmentation

With a combination of phenotyping and genetic data, researchers document at PNAS a Tibetan-enriched enhancer variant influencing melanin synthesis and ultraviolet light response.

Domestication Linked to Nervous System Genes in Inbred Mouse Strains

Researchers highlighted more than 300 positively selected genes in domesticated mice, including genes linked to nervous system function or behavior in Genome Biology.

ALS Genetic Testing May Be Informative Across Age Ranges, Study Finds

Researchers in the journal Brain identified clinically actionable variants in a significant subset of older ALS patients, prompting them to point to the potential benefits of broader test use.