The Medical Research Council's Paul Burgoyne led a team that used transgenic mice and microarrays to find a gene that contributes to the post-meiotic silencing of genes on the long arm of the mouse Y chromosome MSYq, information that "is crucial for postmeiotic repression of the sex chromosomes and for sperm differentiation." With mice made to produce siRNAs targeting the MSYq gene Sycp3-like Y-linked, or Sly, they found that less Sly expression led to mice with "major sperm differen