This Week in PLoS

In work appearing this week in PLoS Biology, scientists led by the University of Toronto's Charles Boone used a blend of phage display, yeast two-hybrid, and peptide array screening to scan billions of peptides in order to find SH3 domain binding partners in S. cerevisiae. After creating a "high-confidence yeast SH3 domain interaction map," they showed that the binding peptides were enriched for proteins involved in endocytosis.

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23andMe's Anne Wojcicki ponders DNA and what it means to be human in a New York Times essay.

A new estimate places the last universal common ancestor to life on Earth as living 3.9 billion years ago, Inverse reports.

In PNAS this week: retinitis pigmentosa gene therapy, role of microbiome in growth stunting, and more.

Bloomberg reports that researchers and drug companies are modeling anti-obesity treatments after the rare genetic condition essential fructosuria.