This Week in PLoS | GenomeWeb

This Week in PLoS

Scientists at Roche have used computational methods to screen for small molecule kinase inhibitors (SMKIs) that bind to more than one kinase and cause damage to chromosomes. Using a competitive binding assay, they tested the binding affinity of 113 SMKIs against a representative subset of all 290 kinases. They were able to identify kinases that correlate with chromosome damage, "providing a basis for rational drug design away from genotoxicity," they say.

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The Wall Street Journal reports that National Institutes of Health Director Francis Collins' response to contamination concerns at the agency might have delayed care.

The final revision of the Common Rule doesn't include the proposed change requiring consent for leftover biospecimens.

The first Reproducibility Project: Cancer Biology papers show mixed results.

In Nature this week: mobile phone-based targeted DNA sequencing, and more.