This Week in PLoS

Scientists at Roche have used computational methods to screen for small molecule kinase inhibitors (SMKIs) that bind to more than one kinase and cause damage to chromosomes. Using a competitive binding assay, they tested the binding affinity of 113 SMKIs against a representative subset of all 290 kinases. They were able to identify kinases that correlate with chromosome damage, "providing a basis for rational drug design away from genotoxicity," they say.

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A federal grand jury has indicted Elizabeth Holmes and Ramesh Balwani for alleged wire fraud in conjunction with their activities at Theranos.

Nature News reports that some developers are nervous about GitHub's acquisition by Microsoft.

A direct-to-consumer genetic testing company sent out used spit kits, CNBC reports.

In PLOS this week: comparison of commercial bisulfite kits, new method to predict essential proteins, and more