This Week in PLoS

In PLoS Computational Biology this week, Michael Brudno published his short read aligner, SHRiMP, or SHort Read Mapping Package, which is a "set of algorithms and methods to map short reads to a genome, even in the presence of a large amount of polymorphism." The software is based on a fast read mapping technique for both regular letter-space and AB SOLiD, or color-space, reads.

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Microsoft co-founder Paul Allen also contributed to brain research, NPR reports.

The New York Times reports on the shifting interpretations of what some genetic variants mean over time.

MIT's Technology Review reports on Genentech's pursuit of personalized cancer vaccines.

In Cell this week: investigation of metastatic tumor evolution, more than 16,000 genetic variants introduced into the budding yeast model organism, and more.