This Week in PLoS

Institute of Pharmaceutical Sciences researchers used a combination of affinity purification and microarrays to study the translational status of every mRNA in S. cerevisiae. Comparing changes in total mRNA levels with ribosome associations, which they call the translatome, they found that severe stress affected both RNA and translatome levels by about 15 percent, whereas mild stress only changed levels by about 1 percent.

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The US Food and Drug Administration has new guidelines that enable some gene and cell therapies to undergo expedited review, according to the New York Times.

Using gene drives to control invasive species might be too risky, an initial advocate of the approach says.

In Science this week: intellectual property experts argue patent battles such as the one over CRISPR are wasteful, and more.

Researchers have grown tumors in 3D cell cultures to better understand cancer, the Economist reports.