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This Week in PLoS: May 11, 2009

Institute of Pharmaceutical Sciences researchers used a combination of affinity purification and microarrays to study the translational status of every mRNA in S. cerevisiae. Comparing changes in total mRNA levels with ribosome associations, which they call the translatome, they found that severe stress affected both RNA and translatome levels by about 15 percent, whereas mild stress only changed levels by about 1 percent. "These networks are preferentially activated for rapid adaptation of cells to minor environmental perturbations," they write in PLoS Biology.

Phil Green at the University of Washington led work studying natural selection in hominid evolution. In a paper in PLoS Genetics, his team looked at sequence changes among five primate species relative to the locations of conserved features, finding that "neutral sequence diversity in human and ancestral hominid populations is substantially reduced near such features," and that average selection is much stronger on protein-coding conserved features than non-exonic ones.

Scientists have concluded that "present databases are not capable of comprehensively retrieving all known metabolites," in work published this week in PLoS One. In scanning databases for both known rice metabolites and computationally derived ones for two sequenced rice variants, oryza japonica and oryza indica, they found that often, "genuine rice metabolites were retrieved together with non-metabolite database entries such as pesticides." Overlaps from database compound lists were hard to compare because structures were either not encoded in machine-readable format or compound identifiers were not cross-referenced between databases, they say.

Also in PLoS One this week, scientists at NYU examined the diversity of 23S rRNA prokaryotic genes, finding that there was "tight ribosomal constraints" on individual 23S rRNA genes within a genome. Looking at 184 species, they found 113 genomes to harbor diversity, eight species showing significant intragenomic variation, and five out of eight showing that changes in primary structure have little effect on secondary structure.

The Scan

Billions for Antivirals

The US is putting $3.2 billion toward a program to develop antivirals to treat COVID-19 in its early stages, the Wall Street Journal reports.

NFT of the Web

Tim Berners-Lee, who developed the World Wide Web, is auctioning its original source code as a non-fungible token, Reuters reports.

23andMe on the Nasdaq

23andMe's shares rose more than 20 percent following its merger with a special purpose acquisition company, as GenomeWeb has reported.

Science Papers Present GWAS of Brain Structure, System for Controlled Gene Transfer

In Science this week: genome-wide association study ties variants to white matter stricture in the brain, and more.