This Week in PLoS

In PLoS One this week, research led in part by Harvard's Martha Bulyk found that short-term calorie restriction in male mice alters global gene expression patterns, making them more like those of female mice. Comparing gene expression data from the livers of male mice fed high calorie or calorie-restricted diets -- known to extend lifespan -- they found that a CR diet changes the expression of more than 3,000 genes, suggesting that a CR diet "feminizes" gene expression.

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