This Week in PLOS

Pennsylvania State University's Marylyn Ritchie and her colleagues report in PLOS Genetics that the natural frequency of rare variants is a common confounder of genetic analyses. The researchers applied a collapsing method called BioBin to whole-genome population data from individuals from 1000 Genomes Project Phase I data to search for aggregate differences in low frequency variation between populations.

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Senate Republicans led by Senator Rand Paul (R-KY) are trying to change how the government funds basic research, reports ScienceInsider.

In Sciencethis week: combining genomics and ecology to better understand the effects of natural selection on evolution, and more.

The US Food and Drug Administration has approved Kite Pharmaceuticals' CAR T-cell therapy for large B-cell lymphomas, the New York Times reports.

Kaiser Health News reports that gene therapies could cost more than a million dollars.