This Week in PLOS

Pennsylvania State University's Marylyn Ritchie and her colleagues report in PLOS Genetics that the natural frequency of rare variants is a common confounder of genetic analyses. The researchers applied a collapsing method called BioBin to whole-genome population data from individuals from 1000 Genomes Project Phase I data to search for aggregate differences in low frequency variation between populations.

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Researchers hope to tease out the signature effects that different carcinogens leave on the genome to determine their contributions to disease, Mosaic reports.

The Wall Street Journal looks into the cost of new gene therapies.

An Imperial College London-led team reports that it was able to use a gene drive to control a population of lab mosquitos.

In PNAS this week: genomic effects of silver fox domestication, limited effect of mitochondrial mutations on aging in fruit flies, and more.