This Week in PLOS

In PLOS Genetics, Duke University's David Goldstein and colleagues from the US and Australia present a scheme for interpreting information in personal genomes. With the help of 6,500 exomes sequenced through the National Heart, Lung, and Blood Institute's Exome Sequencing Project, the group came up with a so-called intolerance scoring system that quantifies the functional variation found in genes relative to their typical level of tolerance to such variability.

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American scientists find themselves once again warning the Trump administration not to dismiss science, the New Yorker report.

A new study suggests CRISPR could be used to save coral reefs from dying off, Forbes reports.

Researchers have found that the i-motif shape of DNA previously observed in the lab also exists in human cells, and that it may serve a purpose.

In PNAS this week: a genomic, transcriptomic, and metabolomic analysis of the tea plant, Arabidopsis thaliana's adaptations to specific local environments, and more.