This Week in PLOS

A study by researchers from Sweden, the US, and elsewhere in PLOS Genetics looks at obesity in light of both genetic and physical activity contributors. Using self-reported physical activity data for 111,421 individuals of European ancestry whose genotype at a dozen obesity-related risk loci had been directly assessed or imputed, the group did a gene-by-activity analysis aimed at understanding whether high levels of activity can dial back genetic obesity risk.

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The US Food and Drug Administration has approved Alnylam's RNAi-based therapy Onpattro, according to Stat News.

Harvard Medical School's Seth Cassel and Cigall Kadoch argue in a Baltimore Sun op-ed that the recent TAILORx trial shows the potential of genomic-based medicine.

Researchers in the UK are working on using gene drives to control malaria-carrying mosquitoes, the Telegraph reports.

In PLOS this week: genetic architecture mediating gene expression, metabolomic patterns in multiple myeloma, and more.