This Week in PLOS

A study by researchers from Sweden, the US, and elsewhere in PLOS Genetics looks at obesity in light of both genetic and physical activity contributors. Using self-reported physical activity data for 111,421 individuals of European ancestry whose genotype at a dozen obesity-related risk loci had been directly assessed or imputed, the group did a gene-by-activity analysis aimed at understanding whether high levels of activity can dial back genetic obesity risk.

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